A2M-ARFGEF2 Fusion FISH Probe


Gene Details
SKU Test Kits Buffer Dye Color Order Now
A2M-ARFGEF2-20-RERE 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-REOR 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-REGO 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-REGR 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-REAQ 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-ORRE 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-OROR 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-ORGO 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-ORGR 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-ORAQ 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-GORE 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-GOOR 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-GOGO 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-GOGR 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-GOAQ 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-GRRE 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-GROR 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-GRGO 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-GRGR 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-GRAQ 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-AQRE 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-AQOR 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-AQGO 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-AQGR 20 (40 μL) 200 μL color color Request Pricing
A2M-ARFGEF2-20-AQAQ 20 (40 μL) 200 μL color color Request Pricing

A2M Summary

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]

A2M Details

Gene Symbol : A2M

Gene Name : Alpha-2-macroglobulin

Chromosome : CHR 12: 911,596,1-906,770,7

Locus : 12p13.31


ARFGEF2 Summary

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]

ARFGEF2 Details

Gene Symbol : ARFGEF2

Gene Name : ADP ribosylation factor guanine nucleotide exchange factor 2

Chromosome : CHR 20: 489,217,20-490,366,92

Locus : 20q13.13


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