This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MDFIBA-20-REGO | 20 (40 μL) | 200 μL |
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| MDFIBA-20-REGR | 20 (40 μL) | 200 μL |
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| MDFIBA-20-ORGR | 20 (40 μL) | 200 μL |
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| MDFIBA-20-GOGR | 20 (40 μL) | 200 μL |
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| MDFIBA-20-GRRE | 20 (40 μL) | 200 μL |
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| MDFIBA-20-GROR | 20 (40 μL) | 200 μL |
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| MDFIBA-20-GRGO | 20 (40 μL) | 200 μL |
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| MDFIBA-20-AQOR | 20 (40 μL) | 200 μL |
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This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. [provided by RefSeq, Jul 2008]
Gene Symbol : MDFI
Gene Name : MyoD family inhibitor
Chromosome : CHR 6: 416,370,19-416,542,45
Locus : 6p21.1
Alt. Genes : CLEC3A
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