ACHE Break Apart FISH Probe

Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
ACHEBA-20-REGO 20 (40 μL) 200 μL color color Request Pricing
ACHEBA-20-REGR 20 (40 μL) 200 μL color color Request Pricing
ACHEBA-20-ORGR 20 (40 μL) 200 μL color color Request Pricing
ACHEBA-20-GOGR 20 (40 μL) 200 μL color color Request Pricing
ACHEBA-20-GRRE 20 (40 μL) 200 μL color color Request Pricing
ACHEBA-20-GROR 20 (40 μL) 200 μL color color Request Pricing
ACHEBA-20-GRGO 20 (40 μL) 200 μL color color Request Pricing
ACHEBA-20-AQOR 20 (40 μL) 200 μL color color Request Pricing

Gene Summary

Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol : ACHE

Gene Name : Acetylcholinesterase (Cartwright blood group)

Chromosome : CHR 7: 100,896,132-100,889,993

Locus : 7q22.1

Alt. Genes : ZNF263

Request Pricing

Lorem Ipsum is simply dummy text of the printing and typesetting industry.

Lorem Ipsum is simply dummy text of the printing and typesetting industry.