Detect TMPRSS2 gene mutations using a specially designed FISH probe from Empire Genomics. The TMPRSS2 FISH probe localizes at the genomic location of the TMPRSS2 gene, allowing you to detect TMPRSS2 duplications, TMPRSS2 deletions, and TMPRSS2 translocations.

TMPRSS2 Gene Summary

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

TMPRSS2 Ideogram