Detect EGFR gene mutations using a specially designed FISH probe from Empire Genomics. The EGFR FISH probe localizes at the genomic location of the EGFR gene, allowing you to detect EGFR duplications, EGFR deletions, and EGFR translocations.

EGFR Gene Summary

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

EGFR Ideogram