This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BCL7A-20-RE | 20 (40 μL) | 200 μL |  |
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| BCL7A-20-OR | 20 (40 μL) | 200 μL |  |
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| BCL7A-20-GO | 20 (40 μL) | 200 μL |  |
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| BCL7A-20-GR | 20 (40 μL) | 200 μL |  |
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| BCL7A-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : BCL7A
Gene Name : BCL tumor suppressor 7A
Chromosome : CHR 12: 122,021,885-122,062,043
Locus : 12q24.31
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